It's been awhile, but I don't remember losing my appetite or anything like that. I was only taking it for about three weeks though; over the course of that time I had begun to gradually forget to take the medication until eventually I stopped altogether.

I did feel some depression one time, a couple of days after I started taking it. But the sensation only lasted for a few hours, and since I knew what was causing it, it was actually more interesting than 'depressing'. However, I've always been what I consider very emotionally stable ( I've been described as cold) and not prone to fits of drama, so that may explain my lack of reaction to Chantix in that way.

I did get nauseous after taking it one day, because I forgot to eat before taking it. I had to run to McDonalds to get a burger, but like halfway through the burger the sickness subsided.

Hope that's been informative.