When people exercise aerobically, their bodies can actually make drugs — cannabinoids, the same kind of chemicals in marijuana.

Giambattista · 10 days

Oh very cool. Yeah that makes sense. There aren't knockout mice but dietary restriction is an interesting way to play with endocannabinoid levels. Thanks for the link!

SodiumKPump · 12 days

No landline. It was addressed to the "household" so basically they just picked my address.

tmiller3192 · 13 days

Yeah it can be pretty challenging but that's part of the fun. Fuel efficiency is one of the things I'm still trying to get better at. Most of the time I run out of fuel before I've managed to get where I want to be.

But aside from that, there are lots of missions that are easier, e.g. you already start the mission in orbit and have to maneuver to a satellite and use the Canadarm to capture it. Then you can do an EVA and "repair" it, which basically means maneuver to it and pretend, lol. It's a lot of fun though. Was nice to see someone post to this subreddit as I don't think I've seen a single submission on my frontpage for this subreddit since I joined.

tmiller3192 · 13 days

It's fairly difficult depending what you want to do. If you just want to fly into orbit that's not terribly difficult, but learning how to plan orbits and intercept the ISS is quite difficult. Granted I haven't been playing it for long and am starting to get the hang of it, it's not impossible or anything. Just takes time. Plan to do a lot of reading of the manuals and watching tutorials which really help.

But it is lots of fun! The amount of time and focus necessary makes those rewarding clicks of attaining a hard dock to the ISS a rewarding and an exhilarating experience.

pigincuffs · 13 days

It's an overactivation of serotonin receptors. You don't need serotonin to get excess activation. I'm not that familiar with the underlying mechanisms of serotonin syndrome insofar as events downstream of 5HT1 and 5HT2 activation, but I do know the lists of pharmacological agents I've seen listed at risk for precipitating serotonin syndrome with SSRIs include psychedelics, e.g. LSD, DMT.

Depending on the dose it may or may not be likely. But as far as I am concerned, someone asking if they can take an SSRI and DMT is asking for trouble and should be advised not to combine these drugs.

pigincuffs · 14 days

It acts on 5-HT receptors. Many times serotonergic toxicity comes from mixing drugs which can result in elevated activation of 5HT receptors through different mechanisms, such as inhibiting transport, inhibiting metabolism, and directly activating those receptors.

I think that while it may be less likely than other drug combinations to produce serotonin syndrome, it's irresponsible to be mixing these drugs if there isn't any clinical need.

pewtertankard · 14 days

omg I love this guy

pigincuffs · 14 days

You could get serotonergic toxicity, aka. serotonin syndrome. I would advise against it.

Giambattista · 17 days

You might have it reversed. There are FAAH knockout mice that lack the primary enzyme for anandamide metabolism and they exhibit elevated anandamide levels.

Giambattista · 17 days

Technically, anything that imparts changes in the body is a drug. Semantics.

Giambattista · 17 days

You would need to fully inhibit 2-AG and AEA metabolism concomitantly to produce full blown THC-like effects, though you can get partial THC-like effects inhibiting only 2-AG metabolism. This of course is modeled in mouse drug discrimination so take it as it is. See Long et al., 2009 for the data.

Giambattista · 17 days

There aren't any mice that have been engineered to lack anandamide as the the biosynthesis of this compound isn't even fully understood. NAPE-PLD (through which was thought to be the primary avenue for AEA biosynthesis) knockout mice have wild-type anandamide levels. Just want to clarify.

pembridge · 18 days

here ya go

clarezza · 18 days

Nicki and Paulo.

androd94 · 19 days

Not really. See Kent Berridge's work. The dopamine = pleasure motif doesn't really hold up experimentally.

Zonged · 1 month

What the hell is this doing in depth hub?

SpOoKy_EdGaR · 1 month

Are you high? You're claiming university researchers aren't allowed access to cannabis. I'm in a university lab. We have access. I don't need to read a book when I can see the plant material for myself.

SpOoKy_EdGaR · 1 month

Cannabinoid researcher here. This is absolutely false. Our lab, as others, has access to the NIDA drug supply which includes cannabis. We have cannabis in our drug freezer at this very minute and conduct inhalation studies in mice.

thcgoat12 · 1 month

Try pub med but google scholar will provide the same, if not better, results. But honestly, if you're unable to figure this out on your own already I'd say you need to get more lab/research experience before you attempt gaining admission to a PhD program in pharmacology. If you were genuinely interested in the field you should already be familiar with the endocannabinoid system. Frankly, you strike me as a pot enthusiast rather than someone who is interested in the science.

callthewambulance · 1 month

While biking the correct direction down a one-way street at night I almost ran into this guy with no light on his bicycle coming head on. He then started to yell at me to watch where I'm going....

Kermit_Porkins · 1 month

Environmental enrichment for lab rodents will increase neuronal growth, dendritic branching in hippocampal neurons, an effect which is also observed with antidepressants. This is important as reduced BDNF and growth/branching of neurons in the hippocampus is something that is observed in depressed patients.

laporkenstein · 1 month

At some point we're going to have to have migrate over to /r/truespace/. Every subreddit turns to shit when the number of users reaches a certain number.

cardboardjames · 1 month

A failure to replicate consistently might hint at that fact though.

Which is my point. How many times are they going to try to attempt to replicate these findings? Even in the hard sciences, it takes quite a long time sometimes to find the experimental configuration in which the effect can be detected.

They should be included, to not do so is an incredible oversight. You must allow people to be able to recreate our experiment, if you do not provide the proper information then you are contributing nothing. We should assume nothing from a single experiment.

Yes, they should be included but the fact of the matter is there isn't room to include every small detail about the environment in which the experiment is being run. More journals should require more detailed methods in a supplementary information section; this is something I completely agree on. But that doesn't change the fact that a couple of failed attempts to replicate a finding means that the original finding was spurious or falsified.

This just seems to be an overly-ambitious attempt. Individual labs have to spend much time to establish a model in order to replicate a published effect. The idea that this group can just establish any procedure and verify results and their results will either confirm or put into question published findings is frankly absurd. I'm all for replicating results but this strikes me as a witch hunt.

cardboardjames · 1 month

Since everyone seems to be fully in support of this, let me take the other side. I really question their ability to replicate this many studies. I mean, a lab is going to take a long time and a lot of care to conduct their experiment, collect their data, and this is after they have spent quite a deal of time working out their procedure.

It almost bothers me that this group is acting like some sort of confirmation board whereby their results will dictate the validity of published studies. A failure to replicate does not necessarily mean the original data are bunk, but possibly* that the experiment is not being properly run. There are many nuances to experimental design that do not get included in the methods.

I like the idea, but I really worry what impact this could have on labs that have run legitimate studies and for whatever reason their results are not replicated. Is there any promise these experiments will have sufficient power? Are they going to be working with the original investigators to ensure they are conducting the experiment in the exact same way?

One does not call into question the findings of another lab unless you've spent quite some time trying to replicate their results. How much time are they going to spend attempting to replicate each experiment?

*edited for clarity

Staneee · 1 month

http://ge.tt/9vtuiVG/v/0

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