Within this seemingly frat-tastic message, there is wisdom. Be somewhat directly flirtatious with the girls from the beginning. Otherwise, you're just a dude, or a friend who wants to talk about vacations and where she went to college and what she does for a living and her favorite restaurants and if she's a cat person or a dog person or if she thinks Casey Anthony was guilty and bla bla bla. Sure these things are important, but save it for the next week when you meet her for a drink. Initially, YOUR ABSOLUTE PRIORITY is to get her to laugh. That is an art that you must learn and develop. If she doesn't laugh, maybe you're not funny, maybe you are funny but she's not, maybe she's nervous, who knows why? Just don't over think it. And be sure to talk to everyone, men, girls, pets, everyone. You're at a party, not a bar, so you have the opportunity to really network and build any girls perception of your social worth. Don't overdo it and be fake, but be sure to have some level of acquaintance with most everyone. The point is, you're there to separate yourself from the other men in her mind. Being some random unknown dude who wants to monopolize her time by discussing her favorite band will not do that. Introducing yourself, then asking her to please hold your beer, handing it to her, then instructing her to now follow you around for the rest of the night, might. God speed.